Evomec Plus 10, 20, 50, 100 or 250ml

Composition: 1 ml contains:
ivermectin...................................10 mg
clorsulon................................................ 100 mg
excipients: glycerol formal, propylene glycol.

Pharmacotherapeutic action: ivermectin is an antiparasitic substance from the class of macrocyclic lactones, isolated from the product obtained by fermentation of an actinomycete called Streptomyces avermitilis. It acts by increasing the permeability of the cell membrane to chlorine ions with the hyperpolarization of nerve or muscle cells, causing paralysis and death of the parasite; it also determines the secretion of gamma aminobutyric acid (GABA) at the level of the nerve synapses of the parasite, thus leading to the interruption of the nerve impulse. Clorsulon (benzenesulfonamide) acts on Fasciola spp. (immature and mature forms) by inhibiting enzymes from the glycolytic cycle (3-phosphoglycerol-kinase and phosphoglycerol-mutase). It is quickly absorbed into the bloodstream, the effective plasma concentration being reached approximately 8 hours after administration.

Target species: cattle.

Indications: in the treatment and control of infestations with:
- gastrointestinal nematodes (adults, L3, L4, inhibiting stages): Ostertagia spp; Bunostomum spp; Haemonchus spp; Toxocara spp; Trichostrongylus spp; Trichocephalus spp; Cooperia spp; Oesophagostomum spp; Nematodirus spp; Chabertia spp; Strongyloides spp.
- pulmonary nematode: Dictyocaulus spp.
- Trematode (adult and immature): Fasciola hepatica; Fasciola gigantea.
- scabies: Sarcoptes scabie var bovis; Choroptes bovis; Psoroptes bovis.
- entomozoans: Hypoderma bovis (larval stages); Hypoderma lineatum (stage larva).
- ectoparasites: Linognatus vituli; Haematopinus eurystemus; Damalinia bovis; ticks.

Method of administration: it is administered strictly subcutaneously in cattle in a dose of 1 ml product/50 kg body weight. It is usually applied twice a year, in spring and autumn, in a single dose, and in the case of scabies, the treatment is repeated every 10-14 days.

Contraindications: do not administer intramuscularly or intravenously. Do not administer in case of hypersensitivity to the active substances or to any of the excipients. The use of lactating animals that produce milk for human consumption is not authorized. Transient edema may occur at the inoculation site. It can be used during pregnancy and lactation.